Ultram brand of TRAMADOL HYDROCHLORIDE CATEGORIES, BRAND NAMES, FORMULARIES & COST OF THERAPY CATEGORIES: Analgesics; Antipyretics; Central Nervous System Agents; FDA Approved 1995 Mar; FDA Class 1S ("Standard Review"); Opiate Agonists (Controlled); Pain BRAND NAMES: Ultram DESCRIPTION Ultram (tramadol hydrochloride) is a centrally acting analgesic to tramadol cod The chemical name for tramadol hydrochloride is (�)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl cyclohexanol hydrochloride to tramadol cod The molecular weight of tramadol hydrochloride is 299 to tramadol cod8 to tramadol cod Tramadol hydrochloride is a white, bitter, crystalline and odorless powder to tramadol cod It is readily soluble in water and ethanol and has a pKa of 9 to tramadol cod41 to tramadol cod The water/n-octanol partition coefficient is 1 to tramadol cod35 at pH 7 to tramadol cod Ultram tablets contain 50 mg of tramadol hydrochloride and are white in color to tramadol cod Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax to tramadol cod CLINICAL PHARMACOLOGY Pharmacodynamics Ultram is a centrally acting synthetic analgesic compound that is not derived from natural sources nor is it chemically related to opiates to tramadol cod Although its mode of action is not completely understood from animal tests, at least two complementary mechanisms appear applicable; binding to �-opioid receptors and inhibition of reuptake of norepinephrine and serotonin to tramadol cod Ultram opioid activity derives from low affinity binding of the parent compound to �-opioid receptors and higher affinity binding of the M1 metabolite to tramadol cod In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in �-opioid binding to tramadol cod The contribution to human analgesia of tramadol relative to M1 is unknown to tramadol cod Tramadol-induced antinociception is only partially antagonized by the opiate naloxone in several animal tests to tramadol cod In addition, tramadol has been shown to tramadol cod

Ultram brand of TRAMADOL HYDROCHLORIDE CATEGORIES, BRAND NAMES, FORMULARIES & COST OF THERAPY CATEGORIES: Analgesics; Antipyretics; Central Nervous System Agents; FDA Approved 1995 Mar; FDA Class 1S ("Standard Review"); Opiate Agonists (Controlled); Pain BRAND NAMES: Ultram DESCRIPTION Ultram (tramadol hydrochloride) is a centrally acting analgesic. The chemical name for tramadol hydrochloride is (�)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl cyclohexanol hydrochloride. The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The water/n-octanol partition coefficient is 1.35 at pH 7. Ultram tablets contain 50 mg of tramadol hydrochloride and are white in color. Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax. CLINICAL PHARMACOLOGY Pharmacodynamics Ultram is a centrally acting synthetic analgesic compound that is not derived from natural sources nor is it chemically related to opiates. Although its mode of action is not completely understood from animal tests, at least two complementary mechanisms appear applicable; binding to �-opioid receptors and inhibition of reuptake of norepinephrine and serotonin. Ultram opioid activity derives from low affinity binding of the parent compound to �-opioid receptors and higher affinity binding of the M1 metabolite. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in �-opioid binding. The contribution to human analgesia of tramadol relative to M1 is unknown. Tramadol-induced antinociception is only partially antagonized by the opiate naloxone in several animal tests. In addition, tramadol has been shown.