Ultram brand of TRAMADOL HYDROCHLORIDE CATEGORIES, BRAND NAMES, FORMULARIES & COST OF THERAPY CATEGORIES: Analgesics; Antipyretics; Central Nervous System Agents; FDA Approved 1995 Mar; FDA Class 1S ("Standard Review"); Opiate Agonists (Controlled); Pain BRAND NAMES: Ultram DESCRIPTION Ultram (tramadol hydrochloride) is a centrally acting analgesic etc. 2.blogspot.com order tramadol The chemical name for tramadol hydrochloride is (�)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl cyclohexanol hydrochloride etc. 2.blogspot.com order tramadol The molecular weight of tramadol hydrochloride is 299 etc. 2.blogspot.com order tramadol8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The water/n-octanol partition coefficient is 1.35 at pH 7. Ultram tablets contain 50 mg of tramadol hydrochloride and are white in color. Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax. CLINICAL PHARMACOLOGY Pharmacodynamics Ultram is a centrally acting synthetic analgesic compound that is not derived from natural sources nor is it chemically related to opiates. Although its mode of action is not completely understood from animal tests, at least two complementary mechanisms appear applicable; binding to �-opioid receptors and inhibition of reuptake of norepinephrine and serotonin. Ultram opioid activity derives from low affinity binding of the parent compound to �-opioid receptors and higher affinity binding of the M1 metabolite. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in �-opioid binding. The contribution to human analgesia of tramadol relative to M1 is unknown. Tramadol-induced antinociception is only partially antagonized by the opiate naloxone in several animal tests. In addition, tramadol has been shown.